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Deadly blasts hit Bombay

Deadly blasts hit Bombay

At least 25 people have been killed after two powerful explosions struck the Indian city of Bombay, also known as Mumbai, local officials say.

Redazione World 25 Aug 2003
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THE FANCONI ANAEMIA/BRCA PATHWAY

THE FANCONI ANAEMIA/BRCA PATHWAY

Fanconi anaemia (FA) is a rare genetic cancer-susceptibility syndrome that is characterized by congenital abnormalities, bone-marrow failure and cellular sensitivity to DNA crosslinking agents. Seven FA-associated genes have recently been cloned, and their products were found to interact with well-known DNA-damage-response proteins, including BRCA1, ATM and NBS1. The FA proteins could therefore be involved in the cell-cycle checkpoint and DNA-repair pathways. Recent studies implicate the FA proteins in the process of repairing chromosome defects that occur during homologous recombination, and disruption of the FA genes results in chromosome instability ”€ a common feature of many human cancers.

Redazione Health 22 Jan 2003
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